Over the years we have seen many active people who have a worsening and significant hip pain. They are getting many opinions as to how to treat their hip pain because for most we see, they have been told “you need a hip replacement,” and they are looking for ways to avoid that surgery. Therefore, after years of physical therapy, anti-inflammatory medications, pain killers, and cortisone injections, and still having a painful hip that is losing function, these people are looking for options.
Hip pain relief – are all hip replacement options being explored?
Someone who suffers constantly from pain and who does not want to learn to live with it may consider hip replacement as their only way to get back to a pain-free life and resumption of their normal activities. Others choose hip replacement because of concerns over losing their independence. This includes concerns over their ability to walk, drive, and perform daily and routine personal chores such as dressing, meal preparation, and hygiene. These same concerns are also brought up by people who do not want to have hip replacement. Hip replacement is a major surgery. The post-recovery rehab can put the person into these same situations that they were hoping to avoid, the inability to drive and be independent for weeks or months.
Some doctors are upset however that patients are not given the full story on hip replacement options and alternatives.
Recently a paper in the Journal of medical Internet research suggested (1) that the treatment of hip arthritis and hip injury, like those of other joint osteoarthritic problems, is redefining itself at a pace probably not seen since the advent of hip replacement surgery. Some doctors are upset however that patients are not given the full story on hip replacement options and alternatives. Despite the availability of evidence-based guidelines for conservative treatment of arthritis, management of degenerated joints is often confined to the use of painkillers and the wait for eventual total joint replacement. This suggests a gap in knowledge for those with arthritis regarding the many different treatment options available to them. How wide a gap? One study published in the journal Osteoarthritis Cartilage suggested that when given time and educational materials to deliberate whether or not to proceed with hip replacement, more patients decide not to have surgery.(2)
The rush to hip replacement because of severe pain. But is the hip as bad as the pain?
A February 2022 study (23) suggests that people, or the brain, my perceive a much more painful hip than the MRI indicates. This is what the paper says: “Hip osteoarthritis is characterized by chronic pain, but there remains a mismatch between symptoms and radiological findings (the pain is worse than the MRI). Recently, brain connectivity (the brains understanding of body parts, like the hip for instance) has been implicated in the modulation of chronic peripheral pain, however its association with perceived pain in hip osteoarthritis is not understood.” To understand why some people felt more hip pain than the MRI revealed patients with hip osteoarthritis were asked to perform activities that the researchers suspected would cause them pain. What they found was “functional connections between brain regions associated with pain are altered in hip osteoarthritis patients, and several connections are modulated by performing painful activity.” In other words pain causes more pain. To remedy this, the hip needs to be made less painful.
Balance Remains Impaired after Hip Replacement
A March 2022 study (26) examined the hoped for positive effects of hip replacement on patient balance. Overall, the evidence found suggested that balance is impaired immediately after surgery and, 4-12 months after surgery, it becomes better than preoperatively, although without reaching the level of healthy subjects. A strong level of evidence was found for hip resurfacing resulting in better balance restoration than total hip replacement, and for strength and ROM exercises after surgery positively influencing balance.
Management and pain relief from hip arthritis
Medicine can offer many options for hip pain relief beyond drugs and medications. Research such as those studies above makes it clear that people with hip arthritis are too often told only about hip replacement as a treatment, so they do not even know about a nonsurgical arthritis treatment option that may be available beyond pain medication or “live with it.” Here is what researchers said in the journal Arthritis Care and Research (3): “Conservative treatment modalities in arthritis of hip or knee are underused, whereas the demand for surgery is rising substantially. To improve the use of conservative arthritis treatments, a more in-depth understanding of the reasons for patients’ treatment choice is required. This study identifies the reasons for choice of treatment in patients with hip or knee osteoarthritis.
Various treatment options were discussed: medication, exercise, physical therapy, injections, surgery, complementary and alternative treatment. Four key themes underlying the choice for or against a treatment were identified:
- treatment characteristics: expectations about its effectiveness and risks, the degree to which it can be personalized to a patient’s needs and wishes, and the accessibility of a treatment;
- personal investment: in terms of money and time;
- personal circumstances: age, body weight, comorbidities and previous experience with a treatment; and
- support and advice: from the patient’s social environment and healthcare providers.”
ConZip, Ultram NSAIDs for hip osteoarthritis
In this section we will explore pain-medications.
An April 2022 study (24) reported the following: “The use of tramadol among osteoarthritis patients has been increasing rapidly around the world, but population-based studies on its safety profile among osteoarthritis patients are scarce. (The researchers here) sought to determine if tramadol use in osteoarthritis patients is associated with increased risks of all-cause mortality, cardiovascular diseases (CVD), venous thromboembolism (VTE), and hip fractures compared with commonly prescribed nonsteroidal anti-inflammatory drugs (NSAIDs) or codeine.”
- Overall, 100,358 OA patients were included (average age: 68 years, 63% females).
- All-cause mortality was higher for tramadol compared to NSAIDs
- For cardiovascular diseases (CVD), no differences were observed between tramadol and NSAIDs.
- Tramadol had a higher risk of venous thromboembolism (VTE) compared to diclofenac.
- Tramadol also had a higher risk of hip fractures compared to diclofenac and Cox-2 inhibitors.
- Osteoarthritis patients initiating tramadol have an increased risk of mortality, venous thromboembolism, and hip fractures within one year compared with commonly prescribed NSAIDs, but not with codeine.
Treated with medication and then hip replacement or arthroscopic surgery and then poor health
The feeling is that when traditional pain-relief treatments and pain medications have run their course and no longer relieve hip pain, hip replacement or arthroscopic surgery is readily available as options to the patients. There is an expectation that surgery fixes everything and improves general overall health and physical well-being and most importantly provides pain relief. There is a lot of expectation. Yet other research says these expectations are not met, and this is clearly cause for concern as post-surgical medications use and drugs for pain relief may be needed after surgery.
Presenting alternatives to hip replacement surgery is an important function in the patient–doctor relationship, as suggested in this recent study published in The Journal of the American Academy of Orthopaedic Surgeons: (4)
“Arthroscopic surgery is commonly performed in the knee, shoulder, elbow, and hip. However, the role it plays in the management of osteoarthritis is controversial. Routine arthroscopic management of osteoarthritis was once common, but this practice has been recently scrutinized. Although some believe that there is no role for arthroscopic treatment in the management of osteoarthritis, it may be appropriate and beneficial in certain situations. The clinical success of such treatment may be rooted in appropriate patient selection and adherence to a specific surgical technique. Arthroscopy may serve as an effective and less invasive option than traditional methods of managing osteoarthritis.”
In other words, as controversial and unproven as arthroscopic surgery is, it may still be better than hip replacement. Far better than both as a first option, in my opinion, are the biomedicine treatments including Bone Marrow Aspirate and Platelet-Rich Plasma (PRP) Therapy. These are non-surgical options for pain relief.
Diagnosing Hip Pain and arthritis – MRI or physical examination
Abnormal findings = surgical procedure.
This simple equation is well documented in the medical literature. Medical journals are filled with studies suggesting that while MRI is frequently used to diagnose conditions affecting the hip, its effectiveness in determining hip pain is not as valuable as a physical examination for determining pain or arthritis problems. MRIs are also not cost effective.(5) MRI is one of the main causes of continued hip pain after surgery.
In the medical journal Pain Physician, doctors agreed, and they offered a commentary that warned physicians that the true causes of hip pain can be easily overlooked and misdiagnosed because of the MRI.(6) This is why an extensive physical examination should be part of the diagnostic process.
Misdiagnosed hip pain can lead to back surgery – patient and doctor over reliance on MRI
We see many people with hip and back pain. Some have been told that they need a hip replacement, some have been told that they need a spinal fusion. Many of been told that they should consider both surgeries. Now these people are trying to decide between one or the other surgery and exploring options to help them avoid one or the other surgery, even both. The problem for some of these people is that they may get a back surgery for a hip problem and a hip surgery for a back problem. Doctors have noted that the symptoms of hip arthritis pain and spinal stenosis leg pain can be very similar, with only subtle differences in both history and clinical physical examinations. Spinal stenosis is classically diagnosed in patients with leg pain that occurs during standing or walking and is relieved when the individual sits down. This is a clinical diagnosis that doctors say can only be confirmed by MRI.
However, in one paper, researchers showed that in as many as 50% of elderly patients, MRI gave a false positive diagnosis of spinal stenosis. Those MRI results might prompt a surgeon to perform spinal surgery. MRI causes more problems. When the hip arthritis symptoms persist and remain undetected, it is even possible that a second unnecessary back surgery could be performed. The following paper reported on patients who had MRI scans and multiple epidural injections and were subjected to repeat back surgeries, all while continuing to complain of their leg pain—the source of which was hip pathology.(7)
This is why some patients continue to experience hip pain after elective hip replacement surgery. One research study advised doctors to look for pain originating from different sources not directly linked to the replacement hardware, as something else must have been the problem.(8) This revelation comes a little late. I see patients who were misdiagnosed and their pain generators overlooked. They have hip pain and an MRI in their chart showing a herniated disc in the lower back. After they had back surgery, the hip arthritis pain remained.
This article should provide a cautionary note for patients who insist that the MRI is providing the evidence needed to end their arthritis pain. In one study of patients who received a hip replacement, researchers noted postoperative complications occurring in almost 20% of the patients. Dislocation was the most common complication, followed by wound infection.(9)
Included in those worries are fresh concerns about the amount of bone loss in the first surgery and the ability to perform a successful revision or future replacement surgery to replace worn-out hardware.(10) This causes obvious concern.
Bone Defects and Bone Death can this only be treated with hip replacement or medication?
For some patients, bone defects in the hip represent a great physical challenge. When the protective cartilage wears away on the “ball” of the hip joint (the femoral head), there can be direct contact with the pelvic acetabulum (part of the pelvis bone in which the femur is seated). For some patients with advanced arthritis or avascular necrosis (bone death) there may be the crunching and grinding of bone on bone.
FIXING THE FEMORAL HEAD MEANS REPLACEMENT
The most-used procedure does not fix the femoral head, instead replacing it (hip replacement) through amputation of the head of the femur and addition of prosthesis (total hip arthroplasty). Since not everyone is suitable for or wants to have the procedure, researchers are exploring ways to fix the femoral head before it becomes unstable or collapses and requires artificial joint replacement.
One method is to patch the bone defects—this is autologous bone grafting. Some of the bone is cut into a patch in the hope that it will take root and grow. However, the amount of bone available for grafting is quite limited as case histories point out.(11)
Regenerating the bone is an appealing remedy, leading researchers to look at bone marrow stem cells, using one’s own stem cells to heal bone defects. In recent research doctors suggested stem cells. The injection of stem cells into the joint can initiate the healing environment in the affected hip, including the regrowth of bone in cases of osteonecrosis (bone death).(12)
The use of stem cells for the treatment of avascular necrosis (bone death due to interruption of the blood supply) of the femoral head presents a new and exciting remedial procedure that medicine is looking into. In pre-clinical studies, the use of stem cells uniformly demonstrates improvements in osteogenesis (bone growth) and angiogenesis (blood vessel formation). In clinical studies, groups treated with stem cells have shown significant improvements in patient-reported outcomes.(13)
The Importance of Bone Health in Hip Replacement
The physical healing of hip arthritis can be complex and complicated, especially if complex and complicated treatments are employed. Once failed surgery exacerbates the matter, it is even more difficult to remedy the hip, especially as the patient ages. The incidence of arthritis is constantly advancing with increased longevity. Aging also leads to an increasing number of patients with osteoporosis (decreased bone mass) who “need” hip replacement for osteoarthritis. Osteoporosis has three major potential complications in total hip arthroplasty: perioperative (that is, near the time of the surgery) fracture, an increased risk of periprosthetic fracture (fracture of bones near the implant), and late aseptic loosening (loosening of hip replacement components). A study examining the effects of osteoporosis on total hip replacement procedure outcome highlights the importance of an adequate study of calciumphosphorus metabolism in patients who are candidates for hip surgery, as well as the need to start a suitable therapy to recover the bone mass before surgery. Poor bone quality of the hip joint is an important risk factor limiting the durability and longevity of the hip replacement.(14) This may lead the patient into life-long use of medications and drugs.
However, if we are prepping the patient for hip replacement by strengthening the bone to hold the artificial devices, why not regrow the bone and cartilage and repair the tissue with the goal of avoiding surgery?
Treating Hip Osteoarthritis Injection Therapy
Can Bone Marrow Aspirate injections and Platelet-Rich Plasma Therapy be effective in treating hip arthritis and in helping you avoid a hip replacement surgery? The answer in many cases is yes. However, success is dependent on a physical examination and a practice of best diagnosis. The hip is a tricky and complex area filled with many pain generator suspects beyond arthritis. The causes of hip pain can be many this is why an extensive physical examination should be part of the diagnostic process.
A March 2022 study (25) examined the use of hip injections. The paper writes:
“Hip injection for osteoarthritis are in vogue nowadays. Corticosteroids and hyaluronic acid gel are the two most common agents injected into the hip. Off late, platelet-rich plasma (PRP), mesenchymal stem cell (MSC), bone marrow aspirate concentrate (BMAC), local anesthetic agents, non-steroidal anti-inflammatory drugs (NSAIDs) and their different combinations have also been injected in hips to provide desired pain relief. . .
. . . Intraarticular corticosteroids are effective in providing the desired pain relief in the osteoarthritis hip, but repeated injections should be avoided and the interval between hip injection and hip arthroplasty must be kept for more than three months.
Chondrotoxic effects of local anesthetic agents is a concern. Although national guidelines do not favor the use of hyaluronic acid for hip osteoarthritis, numerous publications have favored its usage for a moderate grade of osteoarthritis. The PRP, mesenchymal stem cell (MSC), and bone marrow aspirate concentrate (BMAC) are treatment options with great potential; however, currently, the evidence is conflicting on their role in hip osteoarthritis.”
Research on corticosteroids
A February 2020 paper (22) suggested that corticosteroid injections had significant efficacy on both immediate and delayed pain relief until 12 weeks after injection, though the injections effectiveness decreased over time. In addition, based on the current evidence, the longer than 12 weeks follow-up data of efficacy are still rarely reported. Previous research failed to demonstrate significant outcomes on pain reduction at both immediate and delayed intervals up to six months after injection. The researchers noted that they found these results surprising in that they had hypothesized the corticosteroid would be more effective.
Research on Platelet-Rich Plasma Therapy for Hip Repair
Platelet-rich plasma (PRP), obtained by withdrawing the patient’s blood and concentrating the platelets, represents a safe, economical, easy to prepare, and easy to inject source of growth factors. Platelets contain numerous growth factors, and a large number of them have specific activity in cartilage regeneration. PRP is able to significantly reduce pain and improve physical joint function.(15)
A study done in 2012 examined patient safety and symptomatic changes among 40 patients receiving Platelet-Rich Plasma (PRP) Therapy for osteoarthritis of the hip. In the study, each joint received three injections of PRP, administered once a week. The primary end point was meaningful pain relief, which was described as a reduction in pain intensity of at least 30% at six months post-treatment.
Secondary end points included reduction in the level of disability of at least 30% and the percentage of positive responders—that is, the number of patients who achieved a greater than 30% reduction in pain and disability.
The results were statistically significant reductions in pain and improvement in function as reported at seven weeks and again at six months.
- Twenty-three patients (58%) reported a clinically relevant reduction of pain (45%).
- Sixteen (40%) of these patients were classified as excellent responders and showed an early pain reduction at six or seven weeks that was sustained at 6 months, accompanied by a parallel
reduction of disability. (16)
From a January 2016 paper: “Results indicated that intra-articular PRP injections offer a significant clinical improvement in patients with hip osteoarthritis without relevant side effects.”(17)
In other research, doctors followed patients who received Stem Cell Therapy for hip, knee, or ankle osteoarthritis and documented such therapeutic benefits as increased walking distance, increased function, and reduced pain.(18)
Patient Expectations Following Hip Resurfacing
Many times a patient will come into our office with a stack of MRIs, a post-surgical report, and a promise that they were told that they could resume their running after a hip resurfacing procedure. Unfortunately for them, the surgery did not meet their expectations. Recently published research in the American Journal of Sports Medicine, says “Running is possible after hip resurfacing, and runners can even return to some level of competition, but this short follow-up series of hip resurfacing in athletes should be interpreted with caution regarding implant survival.”(19)
Lessen Your Expectations as to physical activity and what sports you can play and at what level – what is the health of your hip?
In the Journal of Bone and Joint Surgery, surgeons warn about sports: “High levels of sporting activities can be detrimental to the long-term success of hip resurfacing devices, independently from other risk factors. Patients seeking hip resurfacing are usually young and should limit their involvement in sports to levels that the implant construct will be able to tolerate.”(20)
Doctor, What is the Difference Between Hip Resurfacing and Hip Replacement?
Hip resurfacing is not hip replacement. In hip resurfacing the head of the femur is capped (after being trimmed) with a smooth metal covering. The damaged bone and cartilage within the socket is removed and replaced with a metal cup, similar to that in a total hip replacement.
In total hip replacement, not only is the head of the femur replaced, but also the socket in the pelvis (acetabulum). One of the main selling points for hip resurfacing is that it leaves more bone so a hip replacement can be performed later.
I see hip resurfacing as one hip surgery setting up another. Surgery in my opinion should always be the last option.
Is Hip Resurfacing Really a Less Invasive Technique?
According to surgeons, hip resurfacing is more difficult to perform and requires a larger incision than typical hip replacement. This increases the risk of complications. For an athlete or a worker whose profession is physically demanding, or any other patient, this can mean unexpected down time and costs.
Does Hip Resurfacing Keep a Younger Patient Active?
Another main selling feature for hip resurfacing as opposed to hip replacement is that studies have shown that it allows the patient to remain more active. However, it is for a limited amount of time. Hip resurfacing has an unknown life span. Thereafter, hip replacement is often necessary.
There can be more issues in relation to the soft tissue needed to stabilize the hip: Doctors in the medical journal Radiographics suggest: “Surgical management for hip disorders should preserve the soft tissue constraints in the hip when possible to maintain normal hip biomechanics.” (21)
This is exactly why we see so many patients after hip surgery. It is too often that the soft tissue that holds the tendons to the bone, or the ligaments that hold the bones to the bones, are compromised. Strengthened ligaments and tendons help hold the hip joint in its proper place, causing less grinding and less bone-on-bone. Restored collagen can help rebuild the cartilage between the pelvis and thighbone, cushioning and relieving the bone-on-bone condition. This is when a consultation for Stem Cell Therapy and Platelet-Rich Plasma Therapy should be considered—and hopefully prior to rather than after surgery: once a prosthesis has been implanted, it is too late to regenerate tissue.
More Hip Problems that May Confuse the Diagnosis
Piriformis syndrome may cause pain in the buttocks, lower back, or down the leg. The piriformis muscle is in the buttocks, attaches to the pelvis and greater trochanter, and helps rotate the leg outward. The sciatic nerve is just beneath it. Occasionally the nerve is impinged beneath the piriformis muscle. When the muscle contracts, it pushes on the nerve, which causes the pain and its radiation down the leg. I rarely see true piriformis syndrome. Typically, the pain is at the enthesis of the piriformis or other buttocks muscles to the bone, and PRP usually heals that with one to three treatments.
GREATER TROCHANTERIC BURSITIS AND ISCHIAL BURSITIS. Persistent hip pain from hip bursitis.
The areas around the hip are covered with and protected by several bursal fluid filled sacs. Each bursa produces lubricating fluid and functions to reduce pressure and friction around the muscles and ligaments over bone. These bursae can become irritated from injury, excessive pressure, and overuse. Inflammation of a bursa is called bursitis. More often this diagnosis is actually a tendinitis or tendinosis. Nevertheless, PRP is usually the correct treatment. Certainly not steroids, like cortisone, which deteriorate the tissue, and can make it worse later.
There is normally a small amount of synovial fluid contained in the hip joint that allows the cartilage on the bones to slide on each other. An excess of this fluid, often caused by overuse or arthritis, can cause pressure and pain in the joint. The fluid comes from synovial tissue surrounding the joint.
I use an ultrasound to visualize the joint, and if an effusion is present, I numb the area and aspirate the fluid. At the same time, platelet rich plasma or stem cells can be injected through the same needle.
Effusions are removed to reduce the joint pressure and to eliminate dilution of the regenerating cells from the patient’s body.
HIP TENDINITIS OR TEARS
Tendinitis occurs when a muscle is overused and pulls on the tendon that attaches it to the bone. In the hip, tendons perform an important role by keeping strong muscles attached to the femur (thighbone) as the legs move. One kind of tendinitis that occurs as a result of overuse is called iliacus tendinitis or iliopsoas tendinitis. The iliac muscle, which starts at the hip bone, and the psoas muscle, which starts in your lower spine, are used when lifting the leg toward the chest. They come together in a tendon at the top of the femur, and that is the point where tendinitis occurs. The problems of the hip can often be treated with Stem Cell Therapy and Platelet-Rich Plasma Therapy. In order to determine if you are a good candidate for this type of procedure, you need to be fully
evaluated by a physician who has significant experience with hip pain.
TERRIBLE SIDE EFFECTS
Unfortunately, too many patients come to me after a hip replacement or other “elective” surgery. The most recent disaster is happening to a very old friend of mine. He is 65 years old, and had both hips replaced for arthritis a few years ago. I previously told him not to do the surgeries and that he really didn’t need them. We had dinner last week, and he told me of an “odd” situation that occurs around his surgical scars. Occasionally, the scar and surrounding tissue becomes red and swollen. None of his doctors can figure out why. Allergy to the prosthetic metal, plastic, or glue inside his body? I didn’t pay much attention since it didn’t sound that bad. He sent me photos of a recent out-break. The area of redness and swelling was about four inches by eight inches. I told him to go directly to the ER since it looked like an infection. He was told by the ER doc that he didn’t know what to do, and that my friend should see a dermatologist.
Unfortunately, no specialist was available for several days in the rural area where my friend lives. I am on pins and needles waiting for the diagnosis, if anyone can figure it out. My guess is that my friend will have to have his prostheses removed and replaced with another material, with the hope that the “allergy” will not return. To me the skin looked so inflamed that if no infection was present, it certainly could occur anytime. I have not told him yet what I am thinking, and am glad this book will not be published for him to read for a couple more months.
I’m not going to implant you with terrible stories of what I have seen after surgeries on many different parts of the body. Since the time I became involved in surgery in 1989, I have seen more bad outcomes than I care to remember. And let me make it clear that I respect surgeons for the difficult and complex work that they do. To me, they are the masters of medicine. Not many of us are willing to bear such standards and responsibilities. However, I must say that in my humble opinion, most elective surgeries should not be done for arthritis. The risks are just too high. Medicine can offer many options for hip pain relief beyond drugs and medications, AND, hip surgery for many people.
1 Umapathy H, Bennell K, Dickson C, Dobson F, Fransen M, Jones G, Hunter DJ. The web-based osteoarthritis management resource my joint pain improves quality of care: a quasi-experimental study. Journal of Medical Internet Research. 2015;17(7):e167.
2 Stacey D, Taljaard M, Dervin G, Tugwell P, O’Connor AM, Pomey MP, Boland L, Beach S, Meltzer D, Hawker G. Impact of patient decision aids on appropriate and timely access to hip or knee arthroplasty for osteoarthritis: a randomized controlled trial. Osteoarthritis Cartilage. 2016 Jan;24(1):99-107.
3 Selten EM, Vriezekolk JE, Geenen R, van der Laan WH, van der Meulen-Dilling RG, Nijhof MW, Schers HJ, van den Ende CH. Reasons for treatment choices in knee and hip osteoarthritis: A qualitative study. Arthritis Care Res. (Hoboken). 2016 Jan 27.
4 Pitta M, Davis W, Argintar EH. Arthroscopic Management of Osteoarthritis. J Am Acad Orthop Surg. 2016 Feb;24(2):74-82. doi: 10.5435/JAAOS-D-14-00258.
5 Keeney JA, Nunley RM, Adelani M, Mall N. Magnetic resonance imaging of the hip: poor cost utility for treatment of adult patients with hip pain. Clin Orthop Relat Res. 2014 Mar;472(3):787-92.
6 Tasoglu O, Sirzai H, Onat SS, Ozgirgin N. Is hip originated pain misdiagnosed? Pain Physician. 2015 Mar-Apr;18(2):E259-60.
7 van Zyl AA. Misdiagnosis of hip pain could lead to unnecessary spinal surgery. SA Orthop J (Pretoria). 2010; 9(4)
8 Ferrata P, Carta S, Fortina M, Scipio D, Riva A, Di Giacinto S. Painful hip arthroplasty: definition. Clin Cases Miner Bone Metab. 2011 May;8(2):19-22.
9 Abbas K, Murtaza G, Umer M, Rashid H, Qadir I. Complications of total hip replacement. J Coll Physicians Surg Pak. 2012 Sep;22(9):575-8.
10 Panegrossi G, Ceretti M, Papalia M, Casella F, Favetti F, Falez F. Bone loss management in total knee revision surgery. Int Orthop. 2014 Jan 10
11 Hernigou P, Flouzat-Lachaniette CH, Delambre J, Poignard A, Allain J, Chevallier N, Rouard H. Osteonecrosis repair with bone marrow cell therapies: state of the clinical art. Bone. 2014 Jul 10. pii: S8756-3282(14)00257-9.
12 Lau RL, Perruccio AV, Evans HM, Mahomed SR, Mahomed NN, Gandhi R. Stem Cell Therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review. BMC Musculoskelet Disord. 2014 May 16;15:156.
13 Houdek MT, Wyles CC, Martin JR, Sierra RJ. Stem cell treatment for avascular necrosis of the femoral head: current perspectives. Stem Cells Cloning. 2014 Apr 9;7:65-70. eCollection 2014.
14 Bottai V, Dell’Osso G, Celli F, Bugelli G1, Cazzella N, Cei E, Guido G, Giannotti S. Total hip replacement in osteoarthritis: the role of bone metabolism and its complications. Clin Cases Miner Bone Metab. 2015 Sep-Dec;12(3):247-50.
15. Civinini R, Nistri L, Martini C, Redl B, Ristori G, Innocenti M. Growth factors in the treatment of early osteoarthritis. Cli. Cases Miner Bone Metab. 2013 Jan;10(1):26-9. doi: 10.11138/ccmbm/2013.10.1.026.
16 Sánchez M, Guadilla J, Fiz N, Andia I. Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip. Rheumatology (Oxford). 2012 Jan;51(1):144-50.
17 Dallari D, Stagni C, Rani N, Sabbioni G, Pelotti P, Torricelli P, Tschon M, Giavaresi G. Ultrasound-guided injection of platelet-rich plasma and hyaluronic acid, separately and in combination, for hip osteoarthritis: a randomized controlled study. Am. Sports Med. 2016 Jan 21.
18 Emadedin M, Ghorbani Liastani M, Fazeli R, Mohseni F, et al. Long-term follow-up of intra-articular injection of autologous mesenchymal stem cells in patients with knee, ankle, or hip osteoarthritis. Arch Iran Med. 2015 Jun;18(6):336-44. doi: 015186/AIM.003.
19 Fouilleron N, Wavreille G, Endjah N, et al. Running activity after hip resurfacing arthroplasty: a prospective study. Am J Sports Med. 2012 Apr;40(4):889-94. doi:
20 Le Duff MJ, Amstutz HC. The relationship of sporting activity and implant survivorship after hip resurfacing. J Bone Joint Surg Am. 2012 May 16;94(10):911-8.
21 Smith MV, Costic RS, Allaire R, Schilling PL, Sekiya JK. A biomechanical analysis of the soft tissue and osseous constraints of the hip joint. Knee Surg Sports Traumatol Arthrosc. 2012 Oct 30.
22 Zhong HM, Zhao GF, Lin T, Zhang XX, Li XY, Lin JF, Zhao SQ, Pan ZJ. Intra-articular steroid injection for patients with hip osteoarthritis: a systematic review and meta-analysis. BioMed Research International. 2020 Feb 24;2020.
23 Railton P, Delaney AJ, Goodyear BG, Matyas J, Lama S, Sutherland GR, Powell JN. Altered activity of pain processing brain regions in association with hip osteoarthritis. Scientific Reports. 2022 Feb 18;12(1):1-9.
24 Li L, Marozoff S, Lu N, Xie H, Kopec JA, Cibere J, Esdaile JM, Aviña-Zubieta JA. Association of tramadol with all-cause mortality, cardiovascular diseases, venous thromboembolism, and hip fractures among patients with osteoarthritis: a population-based study. Arthritis Research & Therapy. 2022 Dec;24(1):1-6.
25 Rampal S, Jaiman A, Tokgöz MA, Arumugam G, Sivananthan S, Singh RS, Zazali SB, Mohaddes M. A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. Joint Diseases and Related Surgery. 2022 Mar 28;33(1):255-62.
26 Di Laura Frattura G, Bordoni V, Feltri P, Fusco A, Candrian C, Filardo G. Balance Remains Impaired after Hip Arthroplasty: A Systematic Review and Best Evidence Synthesis. Diagnostics. 2022 Mar 11;12(3):684.