Information on Tennis elbow and elbow pain

Marc Darrow MD, JD.

We will often see patients who have lingering elbow pain. They continue to receive and remedy themselves with traditional “conservative” treatments that include resting, icing, anti-inflammatory medications, Kinesio tape and various other health care provided treatments including physical therapy, massage, cortisone injections and even acupuncture. While some will respond to these treatments the patients who come into our office have not. They have been scheduled for one of the many surgical procedures often suggested for treatment of lateral epicondylitis. Most will be recommended to a debridement, the removal of tissue “too far gone,” to be saved. For many, removing tissue may not be their optimal way way to go. These people will reach out to us to discuss the realistic surgical alternatives we can offer. In this report we will discuss Platelet Rich Plasma Therapy and bone marrow stem cell therapy as well as look at some new research on tennis elbow surgery.

Tennis elbow in office workers and laborers

There is a great probability that the people reading this article have been diagnosed with tennis elbow that have never played tennis in their life. We have seen patients with tennis elbow who were carpenters, rock climbers, office workers, landscapers, golfers, and more. Many never having picked up a racquet.

  • Tennis Elbow (lateral epicondylitis) is a term for severe elbow tendonitis, or an inflammation, soreness, or pain on the outside (lateral) part of the upper arm near the elbow.
  • The cause is usually common extensor tendinosis or a partial tear in the tendon fibers, which connect muscle to the bone. Of the tendinopathies, the traditional term tendinitis refers to the acute (recent) inflammatory stage of tendon injury, while the new term, tendinosis refers to the chronic injury when inflammatory cells are no longer seen, but the tendon is worn.
  • Symptoms include elbow pain that gradually worsens and radiates outside of the elbow to the forearm and to the back of the hand.

While many of these people have never picked up a racquet, they usually have picked up a shopping cart filled with elbow tapes, braces, and sleeves that they hope will help them.

Patients with tennis elbow may not respond to the conventional treatments of “wait, rest, and medicate for pain relief.” For many patients, this slow track to healing is not on their schedule. Most patients prefer getting on with their lives by fast-forwarding the healing process. So they try many things. Some work. Some don’t.

Why tape, sleeves and physical therapy did not help your tennis elbow pain

Some people find great comfort in taping up their elbow or getting elbow sleeves. If it helps, then it is a good thing. For many however, sleeves, kinesiotaping, and ace bandages are not really helpful. Some people get great benefit from physical therapy.

A study from July 2019 (1) had three groups of people (10 in each group) with a new onset of elbow pain go to physical therapy. At the physical therapist’s they would receive treatment and taping.

  • Ten patients received kinesiotaping plus exercises
  • Ten patients received sham taping (Tape that would not help) plus exercises
  • Ten patients received  exercises only.


  • “Kinesiotaping in addition to exercises is more effective than sham taping and exercises only in improving pain in daily activities and arm disability due to lateral epicondylitis.” In other words, this conservative care option of kinesiotaping did not fix the problem of the elbow degeneration.

But, despite this people still go online and buy expensive elbow braces. Why? As many patients say. “it gives me comfort.”

Cortisone, Kinesiotaping, Rest – According to one study – they are only short term relief remedies for tennis elbow pain

A March 2021 study (2) compared early results of Kinesio tape as an alternative method for the treatment of lateral epicondylitis with those of corticosteroid injection and the rest-and-medication group. Among the fifty patients (53 elbows), Kinesio tape was applied to 20 patients (21 elbows), and corticosteroid injection was applied to 15 patients (17 elbows).

Fifteen patients were included in the rest-and-medication group. Patients in the rest-and-medication group were informed about their condition, and necessary warnings were given. No oral or topical treatments were recommended. If needed, paracetamol or nonsteroidal anti-inflammatory drugs (NSAIDs) were prescribed.

  • Improvements in all (pain and function testing) scores were statistically significant in all groups at the end of the second week.
  • At the end of the fourth week, there was also a statistically significant improvement in all three groups, but these improvements were not as high as they were in the first 2 weeks.
  • There was a slight deterioration in the functional scores in the rest-and-medication group and corticosteroid injection groups, while the improvement in the Kinesio tape group continued.
  • However, there was no significant difference between the Kinesio tape, the rest-and-medication group and the corticosteroid groups at the fourth week.
  • Conclusions: Corticosteroid,  Kinesio tape and rest-and-medication treatments were all effective in terms of pain reduction and functional scores at the end of week 2, and the only treatment that continued to be effective in the final week was Kinesio tape.

Ultrasound (US) therapy, extracorporeal shock wave therapy (ESWT), and Kinesio taping comparison study

A February 2021 study (3) aimed to compare the clinical and sonographic effects of ultrasound (US) therapy, extracorporeal shock wave therapy (ESWT), and Kinesio taping (KT) in the lateral epicondylitis. A total of 40 patients with lateral epicondylitis were included. The patients were randomly assigned to 3 treatment groups: ultrasound (US) therapy, ESWT, and Kinesio taping groups.

Pain scores significantly decreased in all groups. Grip strength significantly increased after eight weeks in only the Kinesio taping (KT). The Patient-Rated Tennis Elbow Evaluation Scale (PRTEE) scores showed significantly elbow pain and disability improvements after 2 weeks and after 8 weeks in the ultrasound (US) therapy group and ESWT groups, and after 8 weeks in the Kinesio taping group. Common extensor tendon (CET) thicknesses significantly decreased after 8 weeks in only the extracorporeal shock wave therapy (ESWT) group.

The study found all three treatments are effective in reducing pain and improving functionality. However, none of these treatment methods were found to be superior to others in reducing the pain and improving functionality.

Why physical therapy may fail

An August 2022 study (4) assessed the effectiveness of physical therapy and therapeutic exercise for rotator cuff-related shoulder pain and lateral elbow tendinopathy. Currently there is, as attested to in this paper, no consensus about the optimal progression type exercise program for these disorders. What the researchers of this study found was general reasons why physical therapy may fail. “Pain was the most frequent benchmark when modulating and progressing the exercises, although other criteria were found such as fatigue or self-perceived ability.” Pain, fatigue, and the patient’s belief in the usefulness of the exercise played a major role in preventing physical therapy from being successful.

Headline: One type of tennis elbow surgery, with a track record of “excellent” results, is found to be no more effective than placebo or sham surgery.

When conservative treatments do not respond, often a patient is suggested to surgery. In 2018, Australian surgeons made headlines when they published their study in the  American Journal of Sports Medicine (5) comparing tennis elbow surgery to placebo surgery.

Here is what the research team wrote:

“A number of surgical techniques for managing tennis elbow have been described. One of the most frequently performed involves excising (shaving away) the affected portion of the extensor carpi radialis brevis (ECRB, a muscle of the forearm). The results of this technique, as well as most other described surgical techniques for this condition, have been reported as excellent, yet none have been compared with placebo surgery.”

When the surgery was compared to a sham surgery, the doctors concluded: “this study failed to show additional benefit of the surgical excision of the degenerative portion of the ECRB over placebo surgery for the management of chronic tennis elbow.” So the surgical removal of damaged tissue did not help the patient anymore than the conservative treatments. How about regenerative treatments?

A reassessment of tennis elbow surgery

In an April 2022 study, researchers found that in previously medical studies (6), patients who received a placebo or no-treatment about 90% of them achieved symptom resolution at one year. In this study the researchers noted: “Surgeons often recommend surgery if symptoms persist despite nonsurgical management, but operations for tennis elbow are inconsistent in their efficacy, and what we know about those operations often derives from observational studies that assume the condition does not continue to improve over time. This assumption is largely untested, and it may not be true. ” Their findings followed that people who had no treatment seemed to do very well after one year and that surgical recommendation maybe premature: “The probability of resolution appears to remain constant throughout the first year of follow-up and does not depend on previous symptom duration, undermining the rationale that surgery is appropriate if symptoms persist beyond a certain point of time. We recommend that clinicians inform people who are frustrated with persisting symptoms that this is not a cause for apprehension, given that spontaneous improvement is about as likely during the subsequent few months as it was early after the symptoms first appeared. Because of the high likelihood of spontaneous recovery, any active intervention needs to be justified by high levels of early efficacy and little or no risk to outperform watchful waiting.”

Approximately 85%-90% of patients respond satisfactorily to conservative treatment, but in resistant patients, surgical treatment is considered

A May 2022 paper (7) wrote: “Approximately 85%-90% of patients respond satisfactorily to conservative treatment, but in resistant patients, surgical treatment is considered. Classic open surgery is successful in between 70% and 97% of patients, similarly to more modern techniques such as arthroscopy. (In this) retrospective study of 47 working-age patients with resistant lateral epicondylitis: 27 underwent arthroscopic surgery and 20 underwent open surgery. ” Between the two procedures, no statistically significant differences were observed between the groups in the reduction in reduced pain or disability socres.  The differences in terms of time off were also not statistically significant. The period of work leave corresponded, on average, to 84 days in the arthroscopy group and 90 days in the open surgery group. Conclusions: “Arthroscopic surgery and open surgery provide similar functional results and pain reduction in the treatment of lateral epicondylitis.”

PRP for tennis elbow research

Platelet Rich Plasma therapy extracts the healing platelets from your blood and then re-injects the Platelet-Rich Plasma into the injured elbow. The research below from leading medical universities and research centers from around the world helps confirm our own observations of these treatments.

A September 2023 paper (8) wrote: “Platelet-rich plasma (PRP) is probably the most widely used orthobiologic treatment modality for the conservative management of tendon, muscle and cartilage injuries. Its effectiveness depends on the underlying pathology and the affected body region. The best evidence exists for the treatment of patellar tendinitis (“jumper’s knee”) and epicondylitis humeri radialis (“tennis elbow”).”

PRP is a controversial subject even among the experts who use the treatment.

As discussed throughout this article, PRP treatment for tennis elbow is looked upon even by doctors who use it as a a controversial treatment for elbow pain. A November 2021 study (9) demonstrates this with the results of a survey that was sent to European doctors who use PRP. What they found was the controversy was not so much over if PRP worked, but how it could work better. This survey showed that

“Consensus of agreement (among the doctors who use the treatment) was only reached for 17/40 (42.5%) statements. For statements on PRP formulation, consensus of agreement was reached in 2/6 statements (33%). Only limited consensus on the contraindications, delivery strategy and delivery technique was achieved.”

In this article I am demonstrating research that suggests when PRP would work, when it would not work. Many times that the treatment does not work is not in the treatment itself, but in the application. How was the treatment given, how was the solution prepared.

A May  2023 paper (10) followed up by suggesting: “the use of orthobiologics, such as platelet-rich plasma (PRP), has been proposed to promote tendon regeneration and is supposed to be a valuable treatment option. However, scientific data are conflicting and the short- and long-time results are controversial.”

PRP injections vs. Cortisone

There are many research papers that compare cortisone or steroid injection and PRP treatments.

The results of a comparative June 2023 study (11) found PRP injections to have more long-lasting benefits than cortisone in cases of Lateral Elbow Tendinopathy. In this study of 64 patients, 29 were men and 35 were women, average age was 40 years with a range from 22 to 60 years two groups were created; a group that would receive an ultrasound guided PRP injection and a group that would receive an ultrasound guided cortisone injection.

The researchers used three scoring surveys to gauge the treatment progress.

The DASH (Disabilities of the Arm, Shoulder and Hand) is a scored questionnaire with results measured in numbers. If a patient reports a 0 score – that means they have no disabilities. The maximum severe disability score is 100.

The Patient-Rated Tennis Elbow Evaluation (PRTEE)  score which is a measure that helps patients rate tennis elbow pain and disability levels from 0 to 10.

VAS Score (VAS) which asks patients to rate overall pain (0 = no pain; 10 = unbearable pain).
Here were the side by side comparisons:

  • VAS score PRP patients 1.25 (out of 10) better than 3.68 in the steroid group
  • DASH score PRP patients 4.00 better than 7.43 in the steroid group.
  • PRTEE score PRP patients 3.96 better than 7.53 in the steroid group.

Treatment was successful in 31 patients in the PRP group (96%), out of which 2 patients showed a recurrence due to an increase in VAS score after 6 months.

Treatment was considered improved in 12 patients in the steroid group, of which 4 showed recurrence in 6 months.

The study suggests that both PRP and steroid injections significantly improved the functional outcomes in terms of VAS score, DASH score, and PRTEE score.

“The response to PRP seems to be favorable when compared to steroid injection for pain management and for patient-reported outcomes in lateral epicondylitis.”

In December 2018 a multi-national team of doctors wrote in the journal Current reviews in musculoskeletal medicine (12) compared PRP treatments to cortisone for tennis elbow. They wrote that:

“The response to PRP seems to be favorable when compared to steroid injection for pain management and for patient-reported outcomes in lateral epicondylitis. PRP injection does not seem to have the potential complications associated with a steroid injection such as skin atrophy, discoloration, and secondary tendon tears.” They also noted that in comparison with extracorporeal shockwave, dry needling, or surgical treatments, (PRP injections in tennis elbow seems to be the best-studied intervention.”

  • University researchers in India suggest Platelet-rich plasma (PRP) offers a better option for the treatment of lateral epicondylitis. In a comparison of PRP and cortisone injections, the doctors say  PRP is a superior treatment option in the long-term. (13)
  • A second study published in the Indian journal of orthopaedics compared single injection of platelet-rich plasma for tennis elbow as compared with single injections of triamcinolone (corticosteroid) and placebo (normal saline) over a short term period.
    • Both the PRP and triamcinolone groups had better pain relief at 3 and 6 months as compared to normal saline group, but at 6 months followup, the PRP group had statistically significant better pain relief than triamcinolone group.
    • In the triamcinolone group, 13 patients had injection site hypopigmentation (loss of skin color) and 3 patients had subdermal (skin and subdermal fat layer) atrophy. (14)
  • In the journal The Physician and sports medicine, doctors found steroid could slightly relieve pain and significantly improve function of elbow in the short-term (2 to 4 weeks, 6 to 8 weeks). PRP appears to be more effective in relieving pain and improving function in the intermediate-term (12 weeks) and long-term (half year and one year). Considering the long-term effectiveness of PRP, the researchers recommend PRP as the preferred option for tennis elbow.(15)
  • Doctors from teaching universities in Thailand examined injections of cortisone, autologous blood injection (simple blood injection) and PRP.  What they found was the blood injection and the PRP injection provided superior results to cortisone for pain reduction and functional improvement. The autologous blood injection had a higher rate of site complication that was significant enough to note.(16)
  • A November 2019 study compared the effectiveness of Platelet Rich Plasma injections versus autologous blood injection (blood without making it Platelet Rich), and cortisone. The findings were “PRP was associated with more improvement in pain intensity and 29 function in the long-term than the comparators.”(17)

In a September 2023 comparison study (18), researchers suggested Exercise therapy was beneficial in decreasing pain regardless of dosage or type. Conflicting results were seen with ultrasound, laser, and shockwave therapy. Corticosteroid injections provided the most short-term pain relief, and platelet-rich plasma and autologous blood injections were most effective in the long term.

Long term-benefit of PRP vs Cortisone

  • Dutch researchers writing in the American Journal of Sports Therapies documented the positive effects of PRP on tennis elbow. Treatment of patients with PRP reduced elbow pain and increased function significantly, exceeding the effect of corticosteroid injection even after a follow-up of 2 years.”(19)
  • British doctors agree – research in the British Journal of Sports Medicine says cortisone should never be used and that injections therapies including PRP can be effective and excellent long-term treatments for elbow pain.(20)

A June 2021 study (21)  also examined the current evidence for the effectiveness of platelet rich plasma (PRP) injections versus corticosteroid injections as treatment interventions for tennis elbow. In this systematic review the researchers examined previously published papers evaluating PRP vs. corticosteroid injections as treatment methods for tennis elbow. Two independent researchers searched and screened for articles that were systematic reviews that directly compared PRP to corticosteroid injections injections for tennis elbow. The results were: Corticosteroid injections were more efficacious for short-term pain relief, and PRP injections were more efficacious for long-term pain relief and improved function. PRP injections appear to be a more effective long-term treatment option than corticosteroid injections for those with tennis elbows who did not respond to conservative management.

A September 2023 study (22) found cortisone injections had more impact in the first month of treatment, but PRP should superioir pain and disability outcomes at both 3 and 6 months follow ups. The study authors added that: “However, these findings must all be viewed with caution as the high risk of bias and moderate to low quality of the included studies may not justify a recommendation of one treatment over another.”

A March 2022 study (23) testing the effectiveness of PRP injections for tennis elbow. This study suggested: “Injection of PRP were, found to be effective in treating tendinopathy and arthritis. . . this “study was conducted to access the functional outcome of PRP injection in tennis elbow patients.” Results “In total, 80 individuals participated in (this) study, of which the average age of the participants was 45-54 There is statistical significance in the difference of means of pain score obtained using both VAS (visual pain score) and MAYO (function ability)  score at 12 weeks and 24 weeks.  . .  In tennis elbow patients, PRP injection shows an effective reduction in pain according to VAS and MAYO score and especially, younger age patients have shown more benefit in terms of pain reduction with PRP treatment.”

Worse pain after corticosteroid injection

A September 2022 paper (24) found a “significant difference in perceived pain VAS (Pain scale of 0 none – 10 worst pain) and disability QuickDASH (11 outcome based questions about physical function and symptoms) between pre-injection and recurrence, showing that the patient’s perceived pain and disability were greater when recurred. (After the initial corticosteroid, if and when pain returned it was felt to be worse by patients). The paper concluded: “Although corticosteroid seems to relieve or mask the pain in the short term, there is a considerable chance of recurrence, and patients may perceive more significant pain and disability that may lead to subsequent injection or precocious surgery.”

However, an October 2023 paper (25) found equal success in using platelet-rich plasma (PRP) or methylprednisolone in the treatment of tennis elbow. In a study of 81 patients, 46 (56.79%) who were injected with methylprednisolone and and 35 (43.20%) who received PRP injection, the doctors found “Both groups were equally satisfied with the treatment they had received. . . The study concluded that there is no difference between outcome and efficacy of both treatment modalities used for the treatment of tennis elbow in alleviating pain at 12 months. ”

Cortisone before surgery. Does it effect outcomes?

A June 2023 study (26) of 99 patients who received corticosteroid injections before surgery, suggests; “The number of preoperative corticosteroid injections does not appear to affect postoperative clinical outcomes of patients with lateral epicondylitis who undergo surgery.”

Long term-benefit of PRP vs Physical Therapy

In some of the more research reported in the surgical journal – Journal of Hand and Microsurgery (27) doctors reviewed and presented their evidence on the effectiveness of PRP injections. They found PRP injections have an important and effective role in the treatment of elbow instability. Here is what they wrote:

  • The majority of sufferers recover within 1 year with conservative management which includes physical therapy. The most effective treatment for chronic lateral epicondylitis, however, is argued amongst experts.
  • In the opinion of this study, after review of the literature, PRP injections have an important and effective role in the treatment of debilitating tennis elbow pathology, in cases where physical therapy has been unsuccessful.
  • Previously, cases that persisted despite physical therapy have been treated with corticosteroid injections. Steroid injections are reported to give short-term pain relief, however the proven recurrence rates and complications (including dermal depigmentation, subcutaneous atrophy, and a theoretical risk of increased tendon rupture) should limit their use.
  • PRP has been shown to provide a continuing long-term benefit in cases of chronic lateral epicondylosis, in the recent literature. It is superior to autologous blood injection injections and placebo/dry needling procedures.

A May 2023 paper (28) compared the effectiveness of platelet-rich plasma injections and ultrasonic tenotomy and debridement for lateral elbow tendinopathy. They found “Ultrasonic tenotomy and debridement and PRP both led to significant improvement in patient pain within the 12-week follow-up period. There was no significant difference in efficacy between the two procedures.”

Can PRP eliminate the need for elbow surgery?

A December 2022 study (29) suggested that Platelet-rich plasma (PRP) injections may alleviate symptoms of chronic medial or lateral epicondylitis. In this study, doctors retrospectively analyzed a total of 55 patients with chronic medial or lateral epicondylitis who had undergone at least 6 months of any conservative treatment before the PRP treatments.

The patients were divided into two groups: the PRP group (25 patients), who received a single injection of autologous PRP to the medial or lateral epicondyle, and the physical therapy group (30 patients), who continued with physical therapy and pain medication.

The primary outcome measures were pain and functional outcomes measured in terms of the following: Patient Related Tennis Elbow Evaluation (PRTEE), Visual Analogue Scale (VAS), and Disabilities of the Arm, Shoulder, and Hand (DASH), which were detected at pre-intervention, 6-, 12-, 24-, and 36-month follow-up.

Secondary outcomes included complications and the need for any surgery at follow-up.

Results: Primary outcome measurements showed significantly better results favoring the PRP group. The PRP group required significantly fewer surgical procedures at follow-up (about one year after treatment), and one case of prolonged pain after injection was detected.

Conclusions: “Patients who underwent PRP injections for epicondylitis resulted in better pain and functional outcomes compared to physiotherapy, and this improvement lasted at least 24 months. They required fewer surgical procedures and achieved faster recovery than the physical therapy group. We recommend PRP for chronic epicondylitis of the elbow before considering surgery when other treatments have failed.”

Ultrasound or palpitation to find the injection site?

A November 2022 paper (30) compared the effectiveness of palpation-guided and ultrasound (US)-guided platelet-rich plasma (PRP) injections in patients with chronic lateral epicondylitis. In this study, 60 patients diagnosed with chronic lateral epicondylitis were  randomly assigned to either the palpation-guided or the US-guided injection group before they received PRP injection. All patients were assessed using the Visual Analog Scale (VAS), Disabilities of the Arm, Shoulder and Hand (DASH) scale, and grip strength at baseline and at one, three, and six months after injection.

The researchers found that statistically similar results between two groups. The VAS and DASH scores improved significantly after the injection at each control, as well as grip strength in both groups

A team of researchers in the United Kingdom wrote in the Journal of orthopaedics (31).

  • “Our study adds to the evidence that PRP injection for intractable lateral epicondylitis of the elbow is an acceptable and useful treatment with improvement in symptoms in 56 out of 64 patients (87.5%). It adds to the literature in that we have tried to ascertain the effect of PRP on reducing the need for a complex, risk laden, surgical intervention. . .we consider PRP injection, for intractable lateral epicondylitis of the elbow, not only a safe but also very effective tool in reducing symptoms and have shown it has reduced the need for surgical intervention in this difficult cohort of patients.”

Chronic elbow instability causing tennis elbows in people with physically demanding jobs and frequency of cortisone injections.

A study published in January 2021 (32) can offer evidence that strengthening and tightening the ligaments and tendons of the elbow can help with elbow pain. This is what the study said:

“Instability can coexist and may be associated with refractory lateral epicondylitis. The risk factors of instability associated with refractory lateral epicondylitis are heavy labor and multiple steroid injections.”

This is what I see in my patients. A person comes in with a history of elbow pain. They go to a few doctors, get the traditional treatments and do not get pain alleviation. Mostly in part because they continue at a job that is considered “heavy labor.” So they go onto get a few cortisone injections to help them at their jobs. The cortisone injections over time has lead to a wearing down or thinning of the ligaments and tendons of the elbow causing instability. Your bones are floating around in a hypermobile, unstable state and are compressing and impinging on nerves and other soft tissue. This instability is what PRP and stem cell therapy can address. By stabilizing the elbow, the tennis elbow pain can now be managed.

A February 2024 paper (33)  compared ultrasound guided dry needling  and ultrasound guided platelet rich plasma (PRP) for common tears of the common extensor tendon.

  • 40 patients diagnosed with lateral epicondylitis were randomly assigned to the two study groups (dry needling and PRP).
  • Results: There was significant improvement in the visual analogue scale pain score (0 – 10 self reported pan) in PRP group compared to the dry needling group at 9 months. However, this difference was not evident at 3 and 6 months follow-up. (PRP was more long-term). Average improvement in common extensor tendon thickness in PRP group  was slightly better than dry needling. There was no difference in tear (if present) healing between both groups at 3 months. However at 6 months follow up, PRP demonstrated significant healing in tear compared to dry needling.
  • Conclusion: “Two injections of Ultrasound guided PRP are more beneficial non operative treatment compared to ultrasound guided dry needling, in lateral epicondylitis.”

MRI validation of tendon recovery following PRP treatments

We are often asked if we suggest an MRI for patients following treatments. Usually the answer is no. If the treatment works then the evidence is in the patients pain and function improving. An August 2022 paper (34) did do after PRP treatment MRI. The MRI results of patients at 6 follow-up visits over a 2-year period after platelet-rich plasma injection in patients with lateral epicondylitis were assessed.

  • Thirty patients who underwent PRP treatment for lateral epicondylitis and sequential MRI evaluation were prospectively enrolled.
  • Significant improvements in the MRI scores occurred by 3 months and continued over a period of 24 months.
  • Continuous tendon recovery assessed by MRI was found during a 2-year period after PRP treatment. Improvements in the MRI scores followed and continued longer than improvements assessed by the clinical scores.

Realistic expectation in bone marrow derived stem cell injections

There are many claims made about the effectiveness of bone marrow derived stem cell therapy. When offering this treatment the doctor and the patient need to have a realistic expectation of the effectiveness of the treatment and if it will help the person’s elbow problems. Many people who seek stem cell therapy have already been advised that they should consider surgery. For some of these people surgery will be very effective. But, as with any medical treatment, surgery can have its undesired effects. Even successful surgery can require months of physical therapy and diminished function.

Is there research in support of bone marrow derived stem cell injections?

Many doctors point to a 2008 paper (35) as one of the earliest suggestions that bone marrow derived stem cells could help people with elbow tendinopathy. In this paper doctors suggested that iliac bone marrow plasma injection after arthroscopic debridement of degenerative tissue( in the elbow) will bring along biological healing. The treatment will not only reduce pain but also improve function in patients with resistant elbow tendonitis.

Study points:

  • Twenty-four patients (26 elbows) with significant persistent pain for an average of 15 months following surgery
  • The doctors applied autologous iliac bone marrow plasma injection following arthroscopic debridement.
  • All patients in this study noted improvement both in pain and function. No complication occurred in any patient.
  • Conclusion: “Biologic treatments in orthopaedics are just beginning to evolve. In the present investigation, the injection of iliac bone marrow plasma after arthroscopic debridement in severe elbow tendinosis demonstrated early recovery of daily activities and clear improvement.”

Bone marrow aspirate concentrate stem cell injections contain plasma rich in growth factors and mesenchymal stem cells

In a 2014 study in the Journal of natural science, biology, and medicine (36)  bone marrow aspirate (containing plasma rich in growth factors and mesenchymal stem cells) injection was found to be an effective treatment for tennis elbow in many patients.

In this research a total of 30 adult patients with previously untreated tennis elbow were administered a single injection of bone marrow aspirate (stem cells and platelets).

  • This concentrate was made by centrifugation of iliac crest bone marrow aspirate.
  • The researchers concluded: Treatment of tennis elbow patients with single injection of bone marrow aspirate showed a significant improvement in short to medium term follow-up. They suggest that in the future, such growth factors and/or stem cells based injection therapy can be developed as an alternative conservative treatment for patients of tennis elbow, especially who have failed non-operative treatment before surgical intervention is taken.

Let’s point out again bone marrow aspirate contains plasma rich in growth factors and mesenchymal stem cells. No separate PRP treatment was given.

More recently a 2018 study in the Journal of orthopaedics (37) commented on the above study:

“Bone marrow aspirate concentrate (BMAC) is an emerging, novel treatment for various bone and cartilage pathology and injury. Similar to other orthobiologic intra-articular injections like hyaluronic acid and PRP, BMAC gives patients the opportunity to restore the natural microenvironment of their damaged or diseased tissue. Bone marrow concentrate is commonly taken from pelvic bone, and contains mesenchymal and hematopoetic stem cells, platelets, growth factors, cytokines, and anti-inflammatory and immunomodulatory cells. . . Further evaluating the efficacy of bone marrow injections, thirty patients who were untreated for Lateral Epicondylitis were evaluated with the Patient-rated Tennis Elbow Evaluation (PRTEE) prior to and following the treatment of a single administration of Iliac Bone Marrow Aspirate. – This concentrate, composed of iliac bone marrow aspirate. . . was effective in simplicity and safety, avoiding further complications as other modes of treatment. Evaluated at 2, 6, and 12 weeks after administration, these patients showed drastic improvement in the two week evaluations, thus showing the efficacy of this treatment’s recovery time. Although (the authors} explained the limitation of their study in long term treatment, they believe that this treatment, when paired with growth factor and other stem cell treatment, can be an effective alternative in lieu of surgery.”

Finally, a 2021 study (38) suggested that generally, bone marrow aspirate concentrate injections can have good impact on tendon injury: “Potential evidence has shown that MSC injection improves pain, joint functional, radiological, and arthroscopic parameters in patients with tendon disorders. Although all the included studies had a small sample size, the results clearly presented MSC dose-dependent responses regarding pain relief.”

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1 Giray E, Bingul DK, Akyuz G. The effectiveness of kinesiotaping, sham taping or exercises only in treatment of lateral epicondylitis: A randomized controlled study. PM&R. 2019 Jan 4.
2 Erpala F, Ozturk T, Zengin EC, Bakir U. Early Results of Kinesio Taping and Steroid Injections in Elbow Lateral Epicondylitis: A Randomized, Controlled Study. Medicina. 2021 Apr;57(4):306.
3 Özmen T, Koparal SS, Karataş Ö, Eser F, Özkurt B, Gafuroğlu TÜ. Comparison of the clinical and sonographic effects of ultrasound therapy, extracorporealshock wave therapy, and Kinesio taping in lateral epicondylitis. Turkish Journal of Medical Sciences. 2021;51(1):76-83.
4 Ortega-Castillo M, Cuesta-Vargas A, Luque-Teba A, Trinidad-Fernández M. The role of progressive, therapeutic exercise in the management of upper limb tendinopathies: A systematic review and meta-analysis. Musculoskeletal Science and Practice. 2022 Aug 8:102645.
5 Kroslak M, Murrell GAC. Surgical Treatment of Lateral Epicondylitis: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Am J Sports Med. 2018 Mar 1:363546517753385. doi: 10.1177/0363546517753385.
6 Ikonen J, Lähdeoja T, Ardern CL, Buchbinder R, Reito A, Karjalainen T. Persistent tennis elbow symptoms have little prognostic value: a systematic review and meta-analysis. Clinical Orthopaedics and Related Research®. 2021 Dec 8:10-97.
7 López-Alameda S, Varillas-Delgado D, De Felipe-Gallego J, González-Granados MG, Hernández-Castillejo LE, García-de Lucas F. Arthroscopic surgery versus open surgery for lateral epicondylitis in an active work population: a comparative study. Journal of Shoulder and Elbow Surgery. 2022 May 1;31(5):984-90.
8 Weishorn J, Spielmann J, Kern R, Mayer J, Friedmann-Bette B, Renkawitz T, Bangert Y. New treatment methods in competitive sports: What can we learn from the medical care of top athletes?. Orthopadie (Heidelberg, Germany). 2023 Sep 22.
9 Evans JP, Maffulli N, Smith C, Watts A, Valderas J, Goodwin V. Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi study. Journal of Orthopaedics and Traumatology. 2021 Dec;22(1):1-0.
10 Schmidt-Horlohé K. Therapie der lateralen und medialen Epikondylopathie. Die Orthopädie. 2023 Apr 13:1-8.
11 Kamble P, Prabhu RM, Jogani A, Mohanty SS, Panchal S, Dakhode S. Is Ultrasound (US)-Guided Platelet-Rich Plasma Injection More Efficacious as a Treatment Modality for Lateral Elbow Tendinopathy Than US-Guided Steroid Injection?: A Prospective Triple-Blinded Study with Midterm Follow-up. Clinics in Orthopedic Surgery. 2023 Jun;15(3):454.
12 Kwapisz A, Prabhakar S, Compagnoni R, Sibilska A, Randelli P. Platelet-Rich Plasma for Elbow Pathologies: a Descriptive Review of Current Literature. Current reviews in musculoskeletal medicine. 2018 Sep 25:1-9.
13 Yadav R, Kothari SY, Borah D.  Comparison of Local Injection of Platelet Rich Plasma and Corticosteroids in the Treatment of Lateral Epicondylitis of Humerus. J Clin Diagn Res. 2015 Jul;9(7):RC05-7. doi: 10.7860/JCDR/2015/14087.6213.
14 Seetharamaiah VB, Gantaguru A, Basavarajanna S. A comparative study to evaluate the efficacy of platelet-rich plasma and triamcinolone to treat tennis elbow. Indian journal of orthopaedics. 2017 May;51(3):304.
15 Mi B, Liu G, Zhou W, Lv H, Liu Y, Wu Q, Liu J. Platelet rich plasma versus steroid on lateral epicondylitis: meta-analysis of randomized clinical trials. The Physician and Sportsmedicine. 2017 Apr 3;45(2):97-104.
16 Arirachakaran A, Sukthuayat A, Sisayanarane T, Laoratanavoraphong S, Kanchanatawan W, Kongtharvonskul J. Platelet-rich plasma versus autologous blood versus steroid injection in lateral epicondylitis: systematic review and network meta-analysis. J Orthop Traumatol. 2015 Sep 11.
17 Tang S, Wang X, Wu P, Wu P, Yang J, Du Z, Liu S, Wei F. Platelet-rich plasma versus autologous blood versus corticosteroid injections in the treatment of lateral epicondylitis: a systematic review, pairwise and network meta-analysis of randomized controlled trials. PM R. 2019 Nov 17. doi: 10.1002/pmrj.12287. [Epub ahead of print]
18 Kinney WR, Anderson BR. Nonoperative Management of Lateral Epicondyle Tendinopathy: An Umbrella Review. Journal of chiropractic medicine. 2023 Sep;22(3):204-11.
19 Gosens T, Peerbooms JC, van Laar W, den Oudsten BL. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. Am J Sports Med. 2011 Jun;39(6):1200-8. Epub 2011 Mar 21.
20 Dong W, Goost H, Lin XB, Burger C, Paul C, Wang ZL, Kong FL, Welle K, Jiang ZC, Kabir K. Injection therapies for lateral epicondylalgia: a systematic review and Bayesian network meta-analysis. Br J Sports Med. 2015 Sep 21. pii: bjsports-2014-094387. doi: 10.1136/bjsports-2014-094387.
21 Kemp JA, Olson MA, Tao MA, Burcal CJ. Platelet-Rich Plasma versus Corticosteroid Injection for the Treatment of Lateral Epicondylitis: A Systematic Review of Systematic Reviews. International Journal of Sports Physical Therapy. 2021;16(3):597.
22 Hohmann E, Tetsworth K, Glatt V. Corticosteroid injections for the treatment of lateral epicondylitis are superior to platelet rich plasma at 1 month but platelet rich plasma is more effective at 6 months: An updated systematic review and meta-analysis of level 1 and 2 studies. Journal of Shoulder and Elbow Surgery. 2023 May 27.
23 Paramanantham M, Seenappa H, Venkataraman S, Shanthappa AH. Functional Outcome of Platelet-Rich Plasma (PRP) Intra-lesional Injection for Tennis Elbow–A Prospective Cohort Study. Cureus. 2022 Mar 8;14(3).
24 Asghari E, Zarifian A, Shariyate MJ, Kachooei A. Perceived Pain Severity and Disability After the Recurrence of Tennis Elbow Following a Local Corticosteroid Injection. The Archives of Bone and Joint Surgery. 2022;10(9):760-5.
25 Shaikh SA, Tahir M, Ahmed N. Clinical efficacy of Platelet-Rich Plasma versus local Methylprednisolone Injection in Lateral Epicondylitis. Pakistan Journal of Medical Sciences. 2023 Sep;39(5):1521.
26 Ha C, Cho W, Hong IT, Park J, Ahn W, Han SH. Effect of Repetitive Corticosteroid Injection on Tennis Elbow Surgery. The American Journal of Sports Medicine. 2023 Jun;51(7):1886-94.
27 Murray DJ, Javed S, Jain N, Kemp S, Watts AC. Platelet-Rich-Plasma Injections in Treating Lateral Epicondylosis: a Review of the Recent Evidence. J Hand Microsurg. 2015 Dec;7(2):320-5. doi: 10.1007/s12593-015-0193-3. Epub 2015 Jul 8.
28 Rupe MW, Fleury IG, Glass N, Kruse R. Efficacy of Ultrasonic Tenotomy and Debridement and Platelet-Rich Plasma Injections for Lateral Elbow Tendinopathy. Journal of Hand Surgery Global Online. 2023 May 18.
29 Annaniemi JA, Pere J, Giordano S. Platelet-Rich Plasma Injections Decrease the Need for Any Surgical Procedure for Chronic Epicondylitis versus Conservative Treatment—A Comparative Study with Long-Term Follow-Up. Journal of Clinical Medicine. 2022 Dec 23;12(1):102.
30 Sağlam G, Alişar DÇ. Ultrasound-guided versus palpation-guided platelet-rich plasma injection for the treatment of chronic lateral epicondylitis: A prospective, randomized study. Archives of Rheumatology. 2023 Mar;38(1):67.
31 Hastie G, Soufi M, Wilson J, Roy B. Platelet rich plasma injections for lateral epicondylitis of the elbow reduce the need for surgical intervention. Journal of orthopaedics. 2018 Mar 1;15(1):239-41.
32 Kholinne E, Liu H, Kim H, Kwak JM, Koh KH, Jeon IH. Systematic Review of Elbow Instability in Association With Refractory Lateral Epicondylitis: Myth or Fact?. The American Journal of Sports Medicine.:0363546520980133.
33 Sharma GK, Patil A, Kaur P, Rajesh S, Drakonaki E, Botchu R. Comparison of efficacy of ultrasound-guided platelet rich plasma injection versus dry needling in lateral epicondylitis—a randomised controlled trial. Journal of Ultrasound. 2024 Feb 23:1-7.
34 Suzuki T, Hayakawa K, Nakane T, Fujita N. Repeated magnetic resonance imaging at six follow-up visits over a 2-year period after platelet-rich plasma injection in patients with lateral epicondylitis. Journal of Shoulder and Elbow Surgery. 2022 Mar 2.
Moon YL, Jo SH, Song CH, Park G, Lee HJ, Jang SJ. Autologous bone marrow plasma injection after arthroscopic debridement for elbow tendinosis. Annals Academy of Medicine Singapore. 2008 Jul 1;37(7):559.
36 Singh A, Gangwar DS, Singh S. Bone marrow injection: a novel treatment for tennis elbow. Journal of natural science, biology, and medicine. 2014 Jul;5(2):389.
37 Tarpada SP, Morris MT, Lian J, Rashidi S. Current advances in the treatment of medial and lateral epicondylitis. J Orthop. 2018 Feb 2;15(1):107-110. doi: 10.1016/j.jor.2018.01.040. PMID: 29657450; PMCID: PMC5895908.
38 Cho WS, Chung SG, Kim W, Jo CH, Lee SU, Lee SY. Mesenchymal Stem Cells Use in the Treatment of Tendon Disorders: A Systematic Review and Meta-Analysis of Prospective Clinical Studies. Ann Rehabil Med. 2021 Aug;45(4):274-283. doi: 10.5535/arm.21078. Epub 2021 Aug 30. PMID: 34496470.

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