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Meniscal
Tear and Osteoarthritis
Researchers writing in The Journal of rheumatology say Meniscal
tear at specific sites shares risk factors with knee OA.
Importantly, meniscal tear is associated with cartilage defect,
loss of cartilage volume, alteration in bone size, and
prevalence of radiographic (osteoarthritis), suggesting that
meniscal tear in non-OA (osteoarthritis) subjects appears to be
an early event in the disease process, and may be a risk factor
for knee cartilage damage and articular structural changes.
Ding C, Martel-Pelletier
J, Pelletier JP, Abram F, Raynauld JP, Cicuttini F, Jones G.
Meniscal Tear as an Osteoarthritis Risk Factor in a Largely Non-Osteoarthritic
Cohort: A Cross-Sectional Study. J Rheumatol. 2007
Apr;34(4):776-784. Epub 2007 Mar 15
OBJECTIVE: To examine the associations between meniscal
tear, knee structure, osteoarthritis (OA) risk factors,
radiographic change, and symptoms in a largely non-osteoarthritic
cohort.
METHODS: This cross-sectional study included 294 subjects with
mean age 47 (SD 6) years, body mass index (BMI) 28 (SD 5), and
58% were female. Meniscal tear, knee cartilage defect score,
quantitative tibial and femoral cartilage volume, and tibial
plateau bone area were determined using T1-weighted fat
saturated magnetic resonance images.
RESULTS: In multivariable analysis, prevalence of
meniscal tear was significantly associated with age (OR 1.06 to
1.12/year, all p < 0.05), BMI (OR 1.06 to 1.11/kg/m(2), all p <
0.05 with the exception of the lateral anterior horn), sex
(women vs men: OR 4.14 to 4.23, p < 0.01 at the medial and
lateral meniscal body site), and family history of OA (OR 1.97
to 2.01, p < 0.05 at the lateral meniscal anterior and posterior
horns). Meniscal tear was associated with a higher tibiofemoral
cartilage defect score at lateral body and all medial sites,
lower tibial and femoral cartilage volume at the lateral
compartment, markedly higher prevalent radiographic OA at medial
compartment, and greater tibial bone area. Moreover, meniscal
tear at the lateral posterior and anterior horns was
significantly associated with WOMAC pain, stiffness, and
function scores.
CONCLUSION: Meniscal tear at specific sites shares risk
factors with knee OA. Importantly, meniscal tear is associated
with cartilage defect, loss of cartilage volume, alteration in
bone size, and prevalence of radiographic OA, suggesting that
meniscal tear in non-OA subjects appears to be an early event in
the disease process, and may be a risk factor for knee cartilage
damage and articular structural changes. |
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Patient's stories herein,
and the language used, is intended to inform and educate. HOWEVER, it
does not imply that you or anyone else will receive the same outcome.
Prolotherapy and other modalities mentioned are medical techniques that
may not be considered mainstream. As with any medical procedure, results
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